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April 1, 1959The Journal of Immunology

Fluorescent Antibody Methods in the Differentiation of Murine and Epidemic Typhus Sera; Specificity Changes Resulting from Previous Immunization

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Key result

Fluorescent antibody methods can differentiate murine from epidemic typhus sera, though previous immunization with epidemic typhus vaccine alters antibody specificity upon subsequent murine typhus infection.

Population

Human beings and guinea pigs convalescent from murine or epidemic typhus fever, including 14 presumed murine…

Design

Other

Authors

RGRobert A. GoldwasserZentrum für KinderheilkundeCSCharles C. ShepardTulane University

Discussion

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Implication

Prior vaccination may confound typhus serology; leaves open need for validated diagnostics accounting for immunization history.

Structured PICO

P
Population
Laboratory study evaluating fluorescent antibody methods to differentiate murine and epidemic typhus sera in human and guinea pig samples.
E
Exposure
Fluorescent antibody staining method (indirect or complement staining) with antibody absorption/inhibition techniques
O
Outcome
Differentiation of murine from epidemic typhus sera and specificity of antibody formedsurrogate

Previous immunization with epidemic typhus vaccine alters the specificity of antibodies produced during subsequent murine typhus infection, complicating serological differentiation.

Cite This Study

Goldwasser et al. (1959) studied Murine and epidemic typhus. Previous epidemic typhus immunization vs. No previous immunization was evaluated on Antibody specificity. Fluorescent antibody methods can differentiate murine from epidemic typhus sera, though previous immunization with epidemic typhus vaccine alters antibody specificity upon subsequent murine typhus infection.

synapsesocial.com/papers/6a941a72f55298cb2cfecf9dhttps://doi.org/10.4049/jimmunol.82.4.373
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Serologic Studies of Primary Epidemic Typhus and Recrudescent Typhus (Brill-Zinsser Disease)1965 · 9 citations
  2. 2Serological response of patients suffering from primary and recrudescent typhus: comparison of complement fixation reaction, Weil-Felix test, microimmunofluorescence, and immunoblotting1994 · 62 citations
  3. 3Production and Characterization of Monoclonal Strain‐Specific Antibodies against Prototype Strains of <i>Rickettsia tsutsugamushi</i>1986 · 39 citations
  4. 4MODIFICATION OF AN IMPROVED ANAEROBE JAR1922 · 12 citations
  5. 5Differentiation of 19S and 7S Complement Fixing Antibodies in Primary Versus Recrudescent Typhus by Either Ethanethiol or Heat.1965 · 33 citations