The Novel HLA‐DQB1*06:03:60 Allele Identified by Next‐Generation Sequencing and Confirmed by Nanopore Sequencing

Q: What does this research mean for the field?

The novel HLA-DQB1*06:03:60 allele exists and differs from HLA-DQB1*06:03:01:01 by a single synonymous nucleotide substitution at position 174 in Exon 2. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Elham Harfouch; Marilyne Gomes; Aicha Hamdaoui; Meriem Merabet; Xavier Chamillard

doi:10.1111/tan.70957

August 28, 2026HLAOpen Access

The Novel HLA‐DQB1*06:03:60 Allele Identified by Next‐Generation Sequencing and Confirmed by Nanopore Sequencing

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Key Points

To identify and characterize a previously undescribed variant allele of the HLA-DQB1 gene.
Screened genomic samples using high-throughput next-generation sequencing to detect novel variants.
Verified the specific sequence variation using long-read nanopore sequencing technology.
Identified HLA-DQB1*06:03:60, which exhibits a single synonymous nucleotide substitution at position 174 in exon 2 relative to HLA-DQB1*06:03:01:01.

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Implication

Genomic sequencing identifies novel HLA-DQB1*06:03:60 allele with an exon 2 synonymous substitution, indicating expanded human leukocyte antigen diversity.

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Cite This Study

Harfouch et al. (2026) studied this question.

synapsesocial.com/papers/6a941ce46c1a8fb52e79e7b7 https://doi.org/10.1111/tan.70957

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The Novel HLA‐DQB1*06:03:60 Allele Identified by Next‐Generation Sequencing and Confirmed by Nanopore Sequencing

Key Points

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Implication

Abstract

Discussion

Cite This Study

The Novel HLA‐DQB1*06:03:60 Allele Identified by Next‐Generation Sequencing and Confirmed by Nanopore Sequencing

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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