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February 1, 2026HLA

Identification of the Novel HLA‐DQB1*06:549 Allele by Next‐Generation Sequencing

Ruby J. Siegel Katrin Hacke Rose M. Ridgley Danielle M. Troop Andrés Jaramillo

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Key Points

The central aim is to identify and characterize the HLA-DQB1*06:549 allele.
Utilized next-generation sequencing for allele identification
Focused on nucleotide substitutions in exon 2
Compared findings to HLA-DQB1*06:02:01:01 allele
Identified a nucleotide substitution in HLA-DQB1*06:549
Confirmed genetic variation from HLA-DQB1*06:02:01:01
Potential implications for understanding immune response

Implication

Analysis identifies a new HLA-DQB1 allele, revealing genetic variation in immune response biomarkers.

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Cite This Study

Siegel et al. (2026) studied this question.

synapsesocial.com/papers/699e91eaf5123be5ed04fc33 https://doi.org/10.1111/tan.70612

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Identification of the novel allele <i>HLA‐DQB1*06:02:61</i> by next‐generation sequencing2024 · 3 citations
2Identification of the Novel Allele, <i>HLA‐DQB1*03:577</i> , by Next‐Generation Sequencing2025
3Identification of the Novel HLA‐DQB1*06:556 Allele by Next‐Generation SequencingOriginal Research · 2026
4The Novel HLA‐DQB1*06:03:60 Allele Identified by Next‐Generation Sequencing and Confirmed by Nanopore SequencingOriginal Research · 2026
5Identification of the Novel HLA‐DQB1*02:02:41 Allele by Next‐Generation SequencingOriginal Research · 2026

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Characterisation of the Novel <i>HLA‐DQB1*06:03:58</i> Allele by Next‐Generation Sequencing2026
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Characterisation of the Novel <i>HLA‐DQA1*03:02:05</i> Allele by Next‐Generation Sequencing2025

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