Genomic sequencing analysis identifies the novel HLA-DQB1*02:02:41 allele, highlighting a single synonymous nucleotide substitution in exon 2.
Key Points
To identify and characterize the genetic sequence of the novel human leukocyte antigen allele HLA-DQB1*02:02:41.
Targeted next-generation sequencing was conducted to sequence the human leukocyte antigen HLA-DQB1 gene locus.
The newly discovered allele HLA-DQB1*02:02:41 differs from the known HLA-DQB1*02:02:01:01 sequence by a single synonymous nucleotide substitution at codon 39 in exon 2.