Identification of the Novel HLA‐DQB1*02:02:41 Allele by Next‐Generation Sequencing

Q: What does this research mean for the field?

The novel HLA-DQB1*02:02:41 allele differs from the established HLA-DQB1*02:02:01:01 allele by a single synonymous nucleotide substitution at Codon 39 in Exon 2. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Elham Harfouch; Bénédicte Pare; Xavier Chamillard; Emilie Letoriellec; Laure Croisille

doi:10.1111/tan.70960

August 30, 2026HLAOpen Access

Identification of the Novel HLA‐DQB1*02:02:41 Allele by Next‐Generation Sequencing

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Key Points

To identify and characterize the genetic sequence of the novel human leukocyte antigen allele HLA-DQB1*02:02:41.
Targeted next-generation sequencing was conducted to sequence the human leukocyte antigen HLA-DQB1 gene locus.
The newly discovered allele HLA-DQB1*02:02:41 differs from the known HLA-DQB1*02:02:01:01 sequence by a single synonymous nucleotide substitution at codon 39 in exon 2.

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Implication

Genomic sequencing analysis identifies the novel HLA-DQB1*02:02:41 allele, highlighting a single synonymous nucleotide substitution in exon 2.

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Harfouch et al. (2026) studied this question.

synapsesocial.com/papers/6a97e29ec562ede874ec6ce9 https://doi.org/10.1111/tan.70960

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Identification of the Novel HLA‐DQB1*02:02:41 Allele by Next‐Generation Sequencing

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Cite This Study

Identification of the Novel HLA‐DQB1*02:02:41 Allele by Next‐Generation Sequencing

Key Points

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Implication

Abstract

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Cite This Study

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