Key result
Circulating growth hormone-binding proteins act as circulating receptors and are positively linked to the growth-promoting action of growth hormone, though their ultimate physiologic role remains to be defined.
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The recognition of circulating growth hormone-binding proteins facilitates investigation of the GH-IGF axis, acting as a circulating receptor.
The recognition of circulating GHBP has added a new element of complexity to the GH-IGF axis. At the same time, it has facilitated investigation of that axis. The nature of the high-affinity GHBP as a “circulating receptor“, is particularly intriguing. This property has been useful for probing the GH receptor in humans, in whom direct receptor measurements are difficult. The high-affinity GHBP is positively linked, directly or indirectly, to the growth-promoting action of GH. Little is known about the significance of the low-affinity GHBP. The ultimate physiologic role of GHBP still remains to be defined. The development of simple and reliable assays for GHBP (46, 50, 116) that can be applied on a routine basis should facilitate the rapid accumulation of new knowledge in this field.
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G Baumann (1993) conducted a review in Growth Hormone-Binding Proteins. Growth Hormone-Binding Proteins was evaluated. Circulating growth hormone-binding proteins act as circulating receptors and are positively linked to the growth-promoting action of growth hormone, though their ultimate physiologic role remains to be defined.
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