Why the study?
Does high affinity GH-BP inhibit GH binding to its receptor and GH action in vitro?
Population
Human, rabbit, and female rat liver, rat adipocytes, and cultured human fibroblasts
Comparison
Purified high affinity GH-binding proteins and… vs Low affinity GH-BP, or absence of BP
Design
Preclinical
Authors
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High-affinity GH-BP may modulate GH signaling in vitro; leaves open its in vivo role in human growth disorders.
Does high affinity GH-BP inhibit GH binding to its receptor and GH action in vitro?
Circulating high affinity GH-BP substantially interferes with binding of GH to its receptor and inhibits GH action in vitro.
Mannor et al. (1991) studied this question.
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