Key result
Enterovirus 75 was identified for the first time in Spain in 8 patients, with 5 cases associated with aseptic meningitis or neurologic symptoms, establishing a novel link between this serotype and aseptic meningitis.
This report documents the first isolation of Enterovirus 75 in Europe and its novel association with aseptic meningitis in children.
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Alerts clinicians to EV75 in Spanish aseptic meningitis; leaves open its prevalence and surveillance needs.
To the Editor: Although most human enterovirus (EV) (genus Enterovirus, family Picornaviridae) infections are asymptomatic, they can cause upper respiratory illness, febrile rash, aseptic meningitis, pleurodynia, encephalitis, acute flaccid paralysis, and neonatal sepsislike disease (1). Most EVs have been implicated in aseptic meningitis, most notably echovirus (E) 30, 9, 6, and 11 and coxsackie B virus (CBV) type 5 (2); other serotypes are less frequently associated with neurologic disease.
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Avellón et al. (2006) conducted a letter in Enterovirus infection and aseptic meningitis (n=106). Enterovirus 75 infection was evaluated on Identification of EV75 isolates and their clinical associations. Enterovirus 75 was identified for the first time in Spain in 8 patients, with 5 cases associated with aseptic meningitis or neurologic symptoms, establishing a novel link between this serotype and aseptic meningitis.
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