September 1, 1994Circulation Research

Cardiolipin-protein complexes and initiation of complement activation after coronary artery occlusion.

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Population

Preclinical model of ischemic myocardium undergoing coronary artery occlusion and reperfusion

Comparison

Coronary artery occlusion followed by reperfusion vs Baseline and 4 to 5 hours after reperfusion

Design

Preclinical

Authors

RRRoger D. RossenHaga Hospital LML H MichaelBaylor College of Medicine HHHal K. HawkinsSemmelweis University

Discussion

Member takes

Implication

May link mitochondrial cardiolipin to early complement activation in reperfusion; hypothesis-generating for targeted therapies in myocardial ischemia-reperfusion.

Structured PICO

Population

Preclinical model of ischemic myocardium undergoing coronary artery occlusion and reperfusion

Intervention

Coronary artery occlusion followed by reperfusion

Comparator

Baseline (before occlusion) and 4 to 5 hours after reperfusion

Outcome

Localization of cardiolipin and binding of C1q and complement components (C3, C5, C9)surrogate

Cardiolipin-protein complexes released from damaged mitochondria during ischemia-reperfusion bind C1q and initiate the complement-mediated inflammatory response.

Cite This Study

Rossen et al. (1994) studied this question.

synapsesocial.com/papers/6a9424451e998d99dafeebea https://doi.org/10.1161/01.res.75.3.546

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Implication

May link mitochondrial cardiolipin to early complement activation in reperfusion; hypothesis-generating for targeted therapies in myocardial ischemia-reperfusion.

Cardiolipin-protein complexes and initiation of complement activation after coronary artery occlusion.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiolipin-protein complexes and initiation of complement activation after coronary artery occlusion.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider