What question did this study set out to answer?

To review the pharmacological actions, therapeutic indications, and appropriate dosing strategies of theophylline in the management of bronchial asthma and reversible airway obstruction.

June 5, 1975New England Journal of Medicine

Dosage of Theophylline in Bronchial Asthma

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Authors

KPKenneth M. PiafskyUniversity of Toronto RORichard I. OgilvieGeneral / Preventive / Lipids

Discussion

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Implication

Clinical review demonstrates the therapeutic mechanisms and dosing of theophylline in bronchial asthma, highlighting smooth muscle relaxation mediated by cyclic AMP.

Key Points

To review the pharmacological actions, therapeutic indications, and appropriate dosing strategies of theophylline in the management of bronchial asthma and reversible airway obstruction.
Reviewed the pharmacological properties, mechanisms of action, and clinical indications of 1,3-dimethylxanthine (theophylline).
Evaluated systemic effects including respiratory stimulation, smooth muscle relaxation, cardiac changes, and diuresis.
Theophylline promotes smooth muscle relaxation in the bronchi and non-cerebral vasculature, stimulates respiration, increases cardiac inotropy and chronotropy, and induces diuresis.
Therapeutic actions in reversible airway obstruction are mediated primarily through the inhibition of phosphodiesterase, resulting in increased levels of intracellular cyclic AMP.

Cite This Study

Piafsky et al. (1975) studied this question.

synapsesocial.com/papers/6a94247b1e998d99dafeec1d https://doi.org/10.1056/nejm197506052922305

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June 5, 1975New England Journal of Medicine

Dosage of Theophylline in Bronchial Asthma

View Full Paper

Ask AI

Bookmark

Authors

KPKenneth M. PiafskyUniversity of Toronto RORichard I. OgilvieGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Clinical review demonstrates the therapeutic mechanisms and dosing of theophylline in bronchial asthma, highlighting smooth muscle relaxation mediated by cyclic AMP.

Key Points

To review the pharmacological actions, therapeutic indications, and appropriate dosing strategies of theophylline in the management of bronchial asthma and reversible airway obstruction.
Reviewed the pharmacological properties, mechanisms of action, and clinical indications of 1,3-dimethylxanthine (theophylline).
Evaluated systemic effects including respiratory stimulation, smooth muscle relaxation, cardiac changes, and diuresis.
Theophylline promotes smooth muscle relaxation in the bronchi and non-cerebral vasculature, stimulates respiration, increases cardiac inotropy and chronotropy, and induces diuresis.
Therapeutic actions in reversible airway obstruction are mediated primarily through the inhibition of phosphodiesterase, resulting in increased levels of intracellular cyclic AMP.

Cite This Study

Piafsky et al. (1975) studied this question.

synapsesocial.com/papers/6a94247b1e998d99dafeec1d https://doi.org/10.1056/nejm197506052922305

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