Key result
In a canine model, 4 months of tachypacing-induced chronic heart failure reduced left ventricular fractional shortening from 37.2% to 13.44% (P<0.05) and caused atrial electrophysiological remodeling.
Why the study?
Does chronic heart failure induce atrial electrophysiological remodeling and create a substrate for atrial fibrillation in a canine model?
Population
Canine model of tachypacing-induced chronic heart failure and controls, along with preliminary study dogs.
Comparison
Tachypacing-induced chronic heart failure vs Healthy controls
Design
Preclinical
Follow-up
4 months
Authors
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Chronic heart failure promotes atrial remodeling in canine models; leaves open human AF substrate validation and therapeutic implications.
Does chronic heart failure induce atrial electrophysiological remodeling and create a substrate for atrial fibrillation in a canine model?
Absolute Event Rate: 13.44% vs 37.2%
p-value: p=<0.05
Chronic heart failure in a canine model induces significant atrial electrophysiological and structural remodeling, creating a substrate for persistent atrial fibrillation.
Sridhar et al. (2009) studied Chronic heart failure and atrial fibrillation (n=15). Tachypacing-induced chronic heart failure vs. Controls was evaluated on Left ventricular fractional shortening (p=<0.05). In a canine model, 4 months of tachypacing-induced chronic heart failure reduced left ventricular fractional shortening from 37.2% to 13.44% (P<0.05) and caused atrial electrophysiological remodeling.
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