In recent years the involvement of T cells in allergic reactions to drugs has been well established. However, several molecular aspects of drug recognition by specific T cells remain still unclear. This review will discuss the known pathways of drug presentations by antigen presenting cells, the recognition of MHC/peptide/drug complexes by specific T-cell receptors, and the activation mechanism of drug-specific T cells.
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Greyerz et al. (1999) studied this question.
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