January 1, 1994Autoimmunity

Localization of 14C Labeled Anti-Streptococcal Cell Membrane Monoclonal Antibodies (anti-SCM mAb) in Mice

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Population

Adult mice

Comparison

Peritoneal injection of six different hybridomas… vs One control mAb

Design

Preclinical

Authors

CLCharles F. LangeRoosevelt University

Discussion

Member takes

Implication

Provides animal evidence of streptococcal antibody cross-reactivity with mammalian tissues; hypothesis-generating for human post-infectious autoimmunity.

Structured PICO

Population

Adult mice

Intervention

Peritoneal injection of six different hybridomas secreting anti-streptococcal cell membrane monoclonal antibodies (anti-SCM mAb) along with [14C] amino acids for biosynthetic labeling

Comparator

One control mAb

Outcome

Tissue associated specific radio-activity (SpAc) and microscopic structural analyses in serum, heart, kidney, lung and skeletal musclesurrogate

Circulating antibodies to streptococcal cell membrane can react in vivo with normal mammalian antigens, confirming their cross-reactivity.

Cite This Study

Charles F. Lange (1994) studied this question.

synapsesocial.com/papers/6a942eff7014397b3d8c11ea https://doi.org/10.3109/08916939408995693

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Implication

Provides animal evidence of streptococcal antibody cross-reactivity with mammalian tissues; hypothesis-generating for human post-infectious autoimmunity.

Localization of 14C Labeled Anti-Streptococcal Cell Membrane Monoclonal Antibodies (anti-SCM mAb) in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Localization of 14C Labeled Anti-Streptococcal Cell Membrane Monoclonal Antibodies (anti-SCM mAb) in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider