Key result
In patients with arterial hypertension and coronary heart disease, impaired capillary blood flow observed in vivo was significantly associated with deterioration of red blood cell aggregation parameters measured in vitro.
Observational (n=88)
No
In vitro blood aggregation parameters measured by laser aggregometry and optical trapping correlate with in vivo microcirculation abnormalities in patients with hypertension and coronary heart disease.
In this work, we compare the blood aggregation parameters measured in vitro by laser aggregometry and optical trapping techniques in blood samples with the parameters of blood rheology measured in vivo by digital capillaroscopy in the nail bed capillaries of patients suffering from the hypertension and coronary heart disease. We show that the alterations of the parameters measured in vivo and in vitro for patients with different stages of these diseases are interrelated. Good agreement between the results obtained with different techniques, and their applicability for the diagnostics of abnormalities of rheological properties of blood are demonstrated.
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Луговцов et al. (2019) conducted an observational in Arterial hypertension and coronary heart disease (n=88). Coronary heart disease and impaired microcirculation vs. Hypertensive patients without coronary heart disease or with normal microcirculation was evaluated on Correlation between in vitro red blood cell aggregation parameters and in vivo capillary blood flow parameters. In patients with arterial hypertension and coronary heart disease, impaired capillary blood flow observed in vivo was significantly associated with deterioration of red blood cell aggregation parameters measured in vitro.
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