What question did this study set out to answer?

To examine the occurrence of Campylobacter pylori in a general population sample and assess its relationship with gastric mucosal morphology and secretory function.

July 1, 1988GutOpen Access

Campylobacter pylori in a sample of Finnish population: relations to morphology and functions of the gastric mucosa.

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Authors

MSM SiuralaUniversity of Helsinki PSP. SipponenIsfahan University of Medical Sciences MKM. KekkiUniversity of Helsinki

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Implication

Population-based study reveals Campylobacter pylori links to gastric acid output and mucosal histology in Finnish adults, indicating reduced bacterial survival in severe atrophic gastritis.

Key Points

To examine the occurrence of Campylobacter pylori in a general population sample and assess its relationship with gastric mucosal morphology and secretory function.
Assessed gastric mucosal morphology and peak acid output in a representative population sample from South Finland (N=179).
Evaluated the presence of Campylobacter pylori across biopsy specimens of normal mucosa, superficial gastritis, and varying grades of atrophic gastritis in both the gastric antrum and body.
Campylobacter pylori was present in 5% of normal antral and 11% of normal body mucosa, increasing to 71% and 91% in superficial gastritis, but declined with worsening atrophic gastritis until it was absent in severe body atrophic gastritis.
Colonization frequency correlated positively with gastric acid output, rising from 10% in subjects with achlorhydria to 100% in individuals with acid output exceeding 30 mmol/h.
Bacterial presence was significantly associated with chronic inflammation but not acute inflammation, and correlated negatively with the extent of intestinal metaplasia in the gastric body.

Cite This Study

Siurala et al. (1988) studied this question.

synapsesocial.com/papers/6a9430ebf55298cb2cfed36f https://doi.org/10.1136/gut.29.7.909

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Implication

Population-based study reveals Campylobacter pylori links to gastric acid output and mucosal histology in Finnish adults, indicating reduced bacterial survival in severe atrophic gastritis.

Campylobacter pylori in a sample of Finnish population: relations to morphology and functions of the gastric mucosa.

Discussion

Member takes

Implication

Key Points

Cite This Study

Campylobacter pylori in a sample of Finnish population: relations to morphology and functions of the gastric mucosa.

Discussion

Member takes

Implication

Key Points

Cite This Study

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