Key result
Female type 2 diabetic carriers of the ACE D allele had a significantly increased risk of diabetic nephropathy progression compared to those with II genotypes (adjusted OR 3.082; p=0.008).
Why the study?
Do ACE I/D and AGT M235T polymorphisms affect the progression of diabetic nephropathy in patients with type 2 diabetes?
Observational (n=525)
Do ACE I/D and AGT M235T polymorphisms affect the progression of diabetic nephropathy in patients with type 2 diabetes?
Odds Ratio: 3.082
p-value: p=0.008
The ACE D allele is associated with an increased risk of diabetic nephropathy progression in female, but not male, Taiwanese patients with type 2 diabetes.
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ACE D allele was associated with higher nephropathy progression risk in female T2D patients; hypothesis-generating and requires prospective validation before clinical consideration.
Tien et al. (2008) conducted an observational in Type 2 diabetes and diabetic nephropathy (n=525). ACE D allele vs. ACE II genotype was evaluated on Progression of diabetic nephropathy (shift to a higher stage or doubling of baseline serum creatinine) (OR 3.082, p=0.008). Female type 2 diabetic carriers of the ACE D allele had a significantly increased risk of diabetic nephropathy progression compared to those with II genotypes (adjusted OR 3.082; p=0.008).
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