Key result
The DD genotype of the ACE gene was associated with approximately 1.4 times higher mean serum ACE activity compared to the II genotype in young Japanese females (p < 0.01).
Why the study?
Is the ACE gene polymorphism associated with serum ACE activity and renin profile in young Japanese females?
Population
108 young Japanese females
Comparison
ACE gene polymorphism (DD, ID, and II genotypes) vs Comparison between different ACE genotypes
Design
Cross-sectional
Authors
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ACE genotyping offers no immediate clinical utility in young Japanese females; leaves open effects on renin profile and outcomes.
Cross-Sectional (n=108)
Is the ACE gene polymorphism associated with serum ACE activity and renin profile in young Japanese females?
Effect estimate: 1.4 times
p-value: p=< 0.01
The ACE gene polymorphism is significantly associated with serum ACE activity levels in young Japanese females, with the DD genotype exhibiting the highest activity.
Tsutaya et al. (1997) reported a cross-sectional. ACE gene polymorphism (DD genotype) vs. II genotype was evaluated on Mean serum ACE activity (1.4 times, p=< 0.01). The DD genotype of the ACE gene was associated with approximately 1.4 times higher mean serum ACE activity compared to the II genotype in young Japanese females (p < 0.01).
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