Key result
The angiotensinogen gene M235T polymorphism was not associated with diabetic nephropathy in patients with type 1 (P=0.92) or type 2 diabetes (P=0.93).
Why the study?
Is the angiotensinogen gene M235T polymorphism associated with diabetic nephropathy or hypertension in patients with diabetes?
Case-Control (n=1,316)
Is the angiotensinogen gene M235T polymorphism associated with diabetic nephropathy or hypertension in patients with diabetes?
p-value: p=0.92
The angiotensinogen gene M235T polymorphism does not appear to play a role in the manifestation of diabetic nephropathy or hypertension in diabetic patients.
No takes yet. Share an insight, caveat, or question.
Null finding in case-control data warrants no genetic testing change; leaves open M235T role in larger prospective diabetic cohorts.
Schmidt et al. (1996) conducted a case-control in Diabetic nephropathy in Type 1 and Type 2 diabetes (n=1,316). Angiotensinogen gene M235T polymorphism vs. Patients without diabetic nephropathy was evaluated on Genotype distribution and allele frequencies of the M235T polymorphism between diabetic patients with or without diabetic nephropathy (p=0.92). The angiotensinogen gene M235T polymorphism was not associated with diabetic nephropathy in patients with type 1 (P=0.92) or type 2 diabetes (P=0.93).
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