Why the study?
Is the 235T/235T genotype of the M235T polymorphism in the angiotensinogen gene associated with an increased risk of diabetic nephropathy in NIDDM patients?
Population
242 White non-insulin-dependent diabetes mellitus patients, comprising 117 with diabetic nephropathy and 125…
Comparison
235T/235T genotype of the M235T polymorphism in… vs All other genotypes at the angiotensinogen locus
Design
Case-control
Authors
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Should not yet alter nephropathy risk assessment in NIDDM; hypothesis-generating association in men leaves causal role and utility open.
Is the 235T/235T genotype of the M235T polymorphism in the angiotensinogen gene associated with an increased risk of diabetic nephropathy in NIDDM patients?
The 235T/235T genotype of the angiotensinogen gene is associated with an increased risk of diabetic nephropathy in men with NIDDM, but not in women.
Freire et al. (1998) studied this question.
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