Why the study?
Is the TT genotype of the AGT gene M235T variant associated with diabetic nephropathy in patients with IDDM?
Population
195 white patients with IDDM born in Northern Ireland and 80 healthy blood donors.
Comparison
Presence of the TT genotype of the M235T variant… vs IDDM patients without nephropathy / absence of…
Design
Case-control
Authors
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May indicate genetic risk for nephropathy in IDDM; hypothesis-generating and requires confirmation before influencing practice.
Is the TT genotype of the AGT gene M235T variant associated with diabetic nephropathy in patients with IDDM?
The TT genotype of the AGT gene M235T variant is associated with an increased risk of diabetic nephropathy in patients with IDDM, potentially explaining the link between hypertension predisposition and nephropathy.
Fogarty et al. (1996) studied this question.
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