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November 1, 1999Journal of Hypertension

Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes

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Why the study?

Are polymorphisms in the ACE and AGT genes associated with hypertension and/or type 2 diabetes?

Population

2,029 individuals from a community-based study, comprising 773 nondiabetic individuals with hypertension…

Comparison

Angiotensin converting enzyme gene… vs Normotensive control individuals and other…

Design

Case-control

Authors

KBKristina BengtssonUniversity of GothenburgMOMarju Orho‐MelanderPreventive CardiologyULUlf LindbladGeneral / Preventive / Lipids

Discussion

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Implication

May support ACE genotyping to stratify hypertension risk in younger diabetics; leaves open prospective validation before clinical use.

Structured PICO

Are polymorphisms in the ACE and AGT genes associated with hypertension and/or type 2 diabetes?

P
Population
2,029 individuals from a community-based study, comprising 773 nondiabetic individuals with hypertension, 193 normotensive patients with type 2 diabetes, 243 patients with type 2 diabetes and hypertension, and 820 normotensive control individuals.
I
Intervention
Angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and angiotensinogen (AGT) gene M235T polymorphism
C
Comparator
Normotensive control individuals and other genotypes
O
Outcome
Association with hypertension and/or type 2 diabetes

The D-allele of the ACE gene ID polymorphism increases susceptibility to hypertension, particularly in individuals with type 2 diabetes, whereas the AGT gene M235T variant shows no such association.

Cite This Study

Bengtsson et al. (1999) studied this question.

synapsesocial.com/papers/6a70f5bc26a7f98052dd67cehttps://doi.org/10.1097/00004872-199917110-00010

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Variation at the Angiotensin-Converting Enzyme Gene and Angiotensinogen Gene Loci in Relation to Blood Pressure1996 · 100 citations
  2. 2M235??? T polymorphism of the angiotensinogen gene predicts hypertension in the elderly1996 · 47 citations
  3. 3Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus.1994 · 229 citations
  4. 4Angiotensinogen as a risk factor for essential hypertension in Japan.1994 · 257 citations
  5. 5A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro.1997 · 550 citations