Key result
M235T and T174M variants of the angiotensinogen gene were not significantly associated with type 2 diabetic nephropathy in a Bangladeshi population.
Why the study?
Marker gene polymorphisms linked with the RAAS have been broadly studied in diabetic nephropathy given RAAS is a potential drug target to slow kidney disease progression, but the link between M235T and T174M variants of the AGT gene and diabetic nephropathy remained to be determined.
Are AGT gene M235T and T174M polymorphisms associated with an increased risk of diabetic nephropathy in a Bangladeshi population?
Case-Control (n=189)
No
Are AGT gene M235T and T174M polymorphisms associated with an increased risk of diabetic nephropathy in a Bangladeshi population?
M235T and T174M variants of the angiotensinogen gene were not significantly associated with diabetic nephropathy in a Bangladeshi population.
Answers are grounded in this paper and cite their sources.
No association seen in this Bangladeshi cohort; leaves open ethnic differences in AGT variant risk for diabetic nephropathy.
Background: Marker gene polymorphisms linked with the renin-angiotensin-aldosterone system (RAAS) have been broadly studied in diabetic nephropathy (DN) patients considering that RAAS is a potential drug target to slow down kidney disease progression. Objectives: The aim of the present study was to determine the link between M235T and T174M variants of angiotensinogen (AGT) gene and DN. Methods: A total of 93 patients with DN, mean age of 56±8 years, systolic blood pressure (SBP) of 141±14, and diastolic blood pressure (DBP) of 84±7 mm Hg (mean±SD) were investigated, among whom 59 patients had a family history of type 2 diabetes mellitus. A total of 96 healthy subjects served as the control group with no family history of diabetic nephropathy (FHDN) and type 2 diabetes mellitus, a mean age of 47±10 years, SBP of 126±11, and DBP of 76±6 mm Hg. PCR–restriction fragment length polymorphism was employed for genotyping M235T and T174M molecular variants. Results: Genotype frequencies of the variants M235T (χ2=2.038, P=0.361) and T174M (χ2=2.952, P=0.229) did not show any statistically significant association with type 2 diabetic nephropathy (T2DN) compared to the control. Based on FHDN and family history of diabetes mellitus (FHDM), the frequency of genotypes of M235T marker (P=0.360) in FHDN, and (P=0.886) FHDM; T174M marker (P=0.641) in FHDN, and (P=0.425) FHDM also did not show any statistically significant association with T2DN compared to the controls. Conclusion: M235T and T174M variants were not associated with DN in a Bangladeshi population.
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Rahman et al. (2022) conducted a case-control in Diabetic nephropathy (n=189). M235T and T174M variants of the angiotensinogen (AGT) gene vs. Healthy controls was evaluated on Association of M235T and T174M variants with type 2 diabetic nephropathy (p=0.361 for M235T; 0.229 for T174M). M235T and T174M variants of the angiotensinogen gene were not significantly associated with type 2 diabetic nephropathy in a Bangladeshi population.
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