Key result
Angiotensinogen gene M235T and T174M polymorphisms were not associated with essential hypertension (P=0.93 and P=0.89, respectively) or target organ damage in a Spanish sample.
Why the study?
Are angiotensinogen gene M235T and T174M polymorphisms associated with essential hypertension or target organ damage in a Spanish population?
Population
150 subjects from a Spanish sample, comprising 75 patients with essential hypertension and 75 healthy…
Comparison
Presence of angiotensinogen gene M235T and T174M… vs Healthy controls and patients without target…
Design
Case-control
Authors
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No support for M235T/T174M testing in hypertension evaluation; hypothesis-generating for other variants in diverse cohorts.
Case-Control (n=150)
Are angiotensinogen gene M235T and T174M polymorphisms associated with essential hypertension or target organ damage in a Spanish population?
p-value: p=0.93
The M235T and T174M variants of the angiotensinogen gene are not associated with essential hypertension or target organ damage in this Spanish cohort.
Patricia Fernández‐Llama (1998) conducted a case-control in Essential hypertension (n=150). Angiotensinogen gene M235T and T174M polymorphisms vs. Healthy controls was evaluated on Genotype frequencies of M235T and T174M variants (p=0.93). Angiotensinogen gene M235T and T174M polymorphisms were not associated with essential hypertension (P=0.93 and P=0.89, respectively) or target organ damage in a Spanish sample.
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