Key result
The AGT T174M polymorphism was not significantly associated with the overall risk of diabetic nephropathy (OR 1.22), although subgroup analysis indicated an increased risk among Asians.
Why the study?
Although the angiotensinogen gene T174M polymorphism has been implicated in diabetic nephropathy pathogenesis, prior study results have been inconsistent.
Is the AGT T174M polymorphism associated with an increased risk of diabetic nephropathy?
Meta-Analysis (n=2,106)
Is the AGT T174M polymorphism associated with an increased risk of diabetic nephropathy?
Odds Ratio: 1.22 (95% CI 0.84–1.75)
The AGT T174M polymorphism is not significantly associated with diabetic nephropathy overall, but may increase risk in Asian populations.
OBJECTIVE:: Although the angiotensinogen ( AGT) gene T174M polymorphism has been implicated in the pathogenesis of diabetic nephropathy (DN), study results have been inconsistent. The present meta-analysis was conducted to determine the correlation of AGT T174M polymorphism with DN. METHODS:: We retrospectively extracted relevant studies from Embase as well as PubMed databases. Additionally, a fixed- or random-effects model was employed for calculation of pooled odds ratio (OR) along with 95% confidence interval (CI). RESULTS:: In total, we identified six studies (1179 cases and 927 controls) regarding the AGT gene T174M polymorphism. The pooled ORs for the association between the AGT T174M polymorphism and DN risk were not statistically significant under all genetic models (M vs T: OR = 1.22, 95% CI = 0.84-1.75; MM vs TT: OR = 1.94, 95% CI = 0.93-4.04; MT vs TT: OR = 1.11, 95% CI = 0.76-1.63; the dominant model: OR =1.19, 95% CI = 0.80-1.77; the recessive model: OR = 1.94, 95% CI = 0.93-4.03). Subgroup analyses based on the type of race showed the M allele of the AGT T174M polymorphism increased DN risk in Asians, but not in Caucasians. CONCLUSIONS:: Our study indicated that the T174M polymorphism in the AGT gene was associated with DN in Asians.
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Liu et al. (2019) conducted a meta-analysis in Diabetic nephropathy (n=2,106). AGT T174M polymorphism vs. Reference genotype (T allele) was evaluated on Risk of diabetic nephropathy (M vs T allele) (OR 1.22, 95% CI 0.84-1.75). The AGT T174M polymorphism was not significantly associated with the overall risk of diabetic nephropathy (OR 1.22), although subgroup analysis indicated an increased risk among Asians.
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