Key result
The AGT M235T polymorphism was significantly associated with coronary artery disease susceptibility in the Eastern Asian population under the heterozygote model (OR 0.19).
Why the study?
Studies linking AGT polymorphism to CAD susceptibility have reported contradictory results, leaving the association unclear in the Eastern Asian population.
Are AGT polymorphisms (M235T and T174M) associated with increased risk of coronary artery disease in the Eastern Asian population?
Meta-Analysis (n=3,470)
Are AGT polymorphisms (M235T and T174M) associated with increased risk of coronary artery disease in the Eastern Asian population?
Odds Ratio: 0.19 (95% CI 0.11–0.33)
p-value: p=≤0.001
The M235T and T174M polymorphisms of the angiotensinogen gene are associated with susceptibility to coronary artery disease in Eastern Asian populations.
AGT M235T/T174M variants were associated with CAD risk in Eastern Asians; leaves open clinical utility pending prospective validation.
BACKGROUND: It is thought that genetic factors may play an important role in the development of coronary artery disease (CAD). Several studies report that AGT polymorphism is implicated in CAD susceptibility, but these results contradict those of the other studies with the associations being unclear in the Eastern Asian population. Therefore, meta-analysis was performed to evaluate this relationship. METHODS: Publication databases were used to search for eligible relevant studies and valid data were extracted from studies meeting the inclusion criteria. Subsequently, odds ratios (ORs) with 95 % confidence intervals (CIs), were used to assess the strength of the association between AGT polymorphism and CAD risk. RESULTS: Seven eligible studies published only in English were included in the present meta-analysis. In the Eastern Asian population, CAD susceptibility was shown to be related to AGT M235T under the heterozygote model (OR = 0.19). Stratified analysis indicated there was a significant relationship between AGT M235T and CAD risk in China under allelic (OR = 1.34), dominant (OR = 1.43), and heterozygote (OR = 1.62) models. The results showed that the T174M polymorphism was significantly associated with CAD risk in recessive (OR = 2.28) and homozygote (OR = 2.37) models in the Eastern Asian population. CONCLUSIONS: In the Eastern Asian population, especially the Chinese, the M235T of AGT is associated with CAD susceptibility. The T174M polymorphisms were associated with CAD risk in the Eastern Asian population.
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Zhang et al. (2022) conducted a meta-analysis in Coronary artery disease (n=3,470). AGT M235T polymorphism vs. MM genotype (wild type) was evaluated on Coronary artery disease susceptibility (heterozygote model, TM vs MM) (OR 0.19, 95% CI 0.11-0.33, p=≤0.001). The AGT M235T polymorphism was significantly associated with coronary artery disease susceptibility in the Eastern Asian population under the heterozygote model (OR 0.19).
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