Key result
The AGT M235T polymorphism recessive genetic model (TT vs MT+MM) was associated with an increased risk of hypertrophic cardiomyopathy in Asian populations (OR 1.27; 95% CI 1.05-1.53).
Why the study?
To explore the relationship between the angiotensinogen gene (AGT) M235T polymorphism and susceptibility to hypertrophic cardiomyopathy in an Asian population.
Is the AGT M235T polymorphism associated with increased susceptibility to hypertrophic cardiomyopathy in Asian populations?
Meta-Analysis
Is the AGT M235T polymorphism associated with increased susceptibility to hypertrophic cardiomyopathy in Asian populations?
Odds Ratio: 1.27 (95% CI 1.05–1.53)
The AGT M235T polymorphism, specifically the TT genotype, is associated with an increased risk of sporadic hypertrophic cardiomyopathy in Asian populations.
AGT M235T recessive model linked to HCM risk in Asians; leaves open need for prospective validation before any genetic screening role.
Objective: To explore the relationship between the polymorphism of angiotensinogen gene (AGT) M235T and susceptibility to hypertrophic cardiomyopathy (HCM) in Asian population by meta-analysis. Methods: PubMed, Embase, Web of Science, Cochrane library, CNKI, Wan Fang, and other databases were searched to collect the literature about AGT M235T polymorphism and HCM from the inception to March 1, 2020. The Newcastle-Ottawa Scale (NOS) checklist was uesd to perform independent literature review and study quality assessment. Data was analyzed by Stata 15.0 software. Results: The results showed that, except for the recessive genetic model (TT vs MT+MM: OR = 1.27, 95%CI: 1.05–1.53), in the other four genetic models, the M235T polymorphism had no significant correlation with the risk of HCM (T vs M: OR = 1.17, 95%CI: 0.88–1.57; TT+MT vs MM: OR = 1.13, 95%CI: 0.55–2.33; TT vs MM: OR = 1.25, 95%CI: 0.60–2.59; TM vs MM: OR = 0.95, 95%CI0.5–1.82). The results of subgroup analysis showed that, except for the heterozygous genetic model, in the other four genetic models, M235T polymorphism was significantly associated with sporadic hypertrophic cardiomyopathy (SHCM), but not with familial hypertrophic cardiomyopathy (FHCM) ( p > 0.05). Conclusion: M235T polymorphism in Asians is associated with HCM, especially SHCM. Heterozygotes increase the risk of patients with SHCM.
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Zhen et al. (2020) conducted a meta-analysis in Hypertrophic cardiomyopathy. Angiotensinogen gene (AGT) M235T polymorphism vs. Other genotypes (e.g., MT+MM) was evaluated on Risk of hypertrophic cardiomyopathy (recessive genetic model TT vs MT+MM) (OR 1.27, 95% CI 1.05-1.53). The AGT M235T polymorphism recessive genetic model (TT vs MT+MM) was associated with an increased risk of hypertrophic cardiomyopathy in Asian populations (OR 1.27; 95% CI 1.05-1.53).
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