Key result
The AGT gene M235T polymorphism was significantly associated with an increased risk of coronary artery disease in the Chinese Han population (homozygote comparison OR 1.54).
Why the study?
Is the AGT gene M235T polymorphism associated with an increased risk of coronary artery disease in the Chinese Han population?
Population
2,281 subjects from 9 case-control studies in the Chinese Han population.
Comparison
Presence of the angiotensinogen gene M235T… vs Absence of the polymorphism (M allele)
Design
Meta-analysis
Authors
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Supports CAD risk stratification in Chinese Han patients; leaves open causal role and clinical utility pending prospective validation.
Meta-Analysis (n=2,281)
Is the AGT gene M235T polymorphism associated with an increased risk of coronary artery disease in the Chinese Han population?
Odds Ratio: 1.54 (95% CI 1.09–2.16)
The AGT gene M235T polymorphism is significantly associated with an increased risk of coronary artery disease in the Chinese Han population.
Wang et al. (2012) conducted a meta-analysis in Coronary artery disease (n=2,281). AGT gene M235T polymorphism (TT genotype) vs. MM genotype was evaluated on Risk of coronary artery disease (OR 1.54, 95% CI 1.09-2.16). The AGT gene M235T polymorphism was significantly associated with an increased risk of coronary artery disease in the Chinese Han population (homozygote comparison OR 1.54).
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