Key result
The AGT M235T T allele was associated with increased CAD risk (OR 1.38; P<0.05), whereas the EL 584C/T T allele was associated with decreased CAD risk (OR 0.83; P<0.05).
Why the study?
The study was conducted to explore the association between the AGT gene M235T variant locus, the EL gene 584C/T locus, and CAD susceptibility.
Are the AGT M235T and EL 584C/T gene polymorphisms associated with susceptibility to coronary artery disease?
Meta-Analysis
Are the AGT M235T and EL 584C/T gene polymorphisms associated with susceptibility to coronary artery disease?
Odds Ratio: 1.38
p-value: p=<0.05
The AGT M235T and EL 584C/T polymorphisms are significantly associated with genetic susceptibility to coronary artery disease.
AGT/EL polymorphisms may refine CAD susceptibility assessment in targeted ancestries; leaves open their integration into clinical risk stratification.
OBJECTIVE: To explore the association between the variant M235T locus of angiotensinogen (AGT) gene, 584C/T locus of Endothelial lipase (EL) gene, and coronary artery disease (CAD) by meta-analysis. METHODS: The case-control studies on the association between AGT/EL gene polymorphism and CAD were collected through searching PubMed, Excerpta Medica Database (EMBASE), Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang databases up to 1 March 2020. Stata 15.0 software was used for analysis. RESULTS: A total of 29 articles met the inclusion criteria. After analyzing, it was found that the M235T polymorphism of AGT gene was associated with the occurrence of CAD. In the allele model (T vs. M), OR = 1.38 (P<v0.05). In other heredity, there was also statistical significance. Subgroup analysis indicated that except the heterozygous genetic model of the Chinese population, other genetic models of the Caucasian and Chinese population were also statistically significant. The 584C/T polymorphism of EL gene was associated with the occurrence of CAD, with OR = 0.83 (P<0.05) in the allele model (T vs. C) and OR = 0.80 (P<0.05) in the dominant gene model. Also, in the allele model of Caucasian subgroup, OR = 0.83 (P<0.05), while in Asian subgroup, there was no statistically significant genetic model. CONCLUSION: AGT M235T and EL 584C/T polymorphisms are associated with CAD susceptibility. The genotype TT, TC or allele T of AGT M235T and genotype CC or allele C of EL 584C/T might be the genetic risk factors for the development of CAD.
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Zhao et al. (2020) conducted a meta-analysis in coronary artery disease (CAD). Variant M235T locus of angiotensinogen (AGT) gene and 584C/T locus of Endothelial lipase (EL) gene vs. Reference alleles (M for AGT, C for EL) was evaluated on occurrence of CAD (OR 1.38, p=<0.05). The AGT M235T T allele was associated with increased CAD risk (OR 1.38; P<0.05), whereas the EL 584C/T T allele was associated with decreased CAD risk (OR 0.83; P<0.05).
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