Key result
Coincubation of platelets with histamine-stimulated endothelial cells increased rap1B phosphorylation by a maximum of 17.5-fold, identifying it as a sensitive marker for platelet inhibition.
Effect estimate: 17.5-fold increase
Measurement of platelet rap1B phosphorylation provides a sensitive tool to monitor the action of cAMP- and cGMP-increasing platelet inhibitors and vasodilators.
No takes yet. Share an insight, caveat, or question.
Rap1B phosphorylation may serve as a sensitive preclinical marker for platelet inhibition; leaves open clinical monitoring utility pending human studies.
Grünberg et al. (1995) studied this question. cAMP- and cGMP-increasing platelet inhibitors and vasodilators was evaluated on rap1B phosphorylation (17.5-fold increase). Coincubation of platelets with histamine-stimulated endothelial cells increased rap1B phosphorylation by a maximum of 17.5-fold, identifying it as a sensitive marker for platelet inhibition.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: