Key result
Platelet-function inhibitors differentially affect fibrinogen binding and ADP secretion, enabling the generation of a model delineating novel regulatory links in the platelet signalling network.
Population
In vitro platelet model
Design
Preclinical
Authors
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Animal models of platelet signaling require human validation before clinical use; leaves open targeted pathway testing in future studies.
This study provides an integrated model of the platelet signalling network, demonstrating how different pathways differentially regulate ADP secretion and fibrinogen binding.
Lombardi et al. (2011) studied this question. Platelet-function inhibitors was evaluated on Fibrinogen binding and ADP secretion. Platelet-function inhibitors differentially affect fibrinogen binding and ADP secretion, enabling the generation of a model delineating novel regulatory links in the platelet signalling network.
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