Key result
GPVI-mediated platelet aggregation by collagen occurs through calcium- and PKC-sensitive pathways independently, without requiring secreted ADP or thromboxane A2.
Population
Platelets (in vitro model)
Design
Preclinical
Authors
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Should not change antiplatelet practice; leaves open human validation of independent calcium/PKC GPVI pathways.
This study demonstrates that GPVI-mediated platelet aggregation relies independently on calcium- and PKC-sensitive pathways, without requiring secreted ADP or thromboxane A2.
Quinton et al. (2002) studied Platelet aggregation. GPVI-selective agonists (convulxin, CRP, collagen) was evaluated on Platelet aggregation and fibrinogen receptor activation. GPVI-mediated platelet aggregation by collagen occurs through calcium- and PKC-sensitive pathways independently, without requiring secreted ADP or thromboxane A2.
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