Key result
Inhibition of either thrombin or ADP reduced aggregate formation during the embolization phase by at least 90%, though neither influenced the initial hemostatic reaction.
In an in vivo rabbit model, thrombin and ADP are not required for initial hemostasis but are essential for long-term thrombus stability and platelet activation during embolization.
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Thrombin/ADP inhibition may prevent embolization without impairing hemostasis; hypothesis-generating for human antithrombotic strategies.
Gestel et al. (2007) studied Hemostasis and thromboembolism. Inhibition of thrombin formation/activity or blockade of platelet ADP receptors P2Y1 and P2Y12 was evaluated on Initial hemostatic reaction, rebleeding frequency, and aggregate formation during embolization. Inhibition of either thrombin or ADP reduced aggregate formation during the embolization phase by at least 90%, though neither influenced the initial hemostatic reaction.
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