Key result
Oxidized LDL induced rapid expression of CD62P and CD63 on platelets, and CD36 contributed to binding and activation, whereas native LDL did not.
Oxidized LDL, but not native LDL, activates platelets and induces rapid expression of CD62P and CD63, with CD36 mediating the binding and activation.
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Oxidized LDL may promote platelet activation via CD36; leaves open relevance to human atherothrombosis.
The significance of three platelet membrane glycoproteins, (CD62p, CD63, and CD36) was studied in platelet interaction with native and copper-oxidized plasma low-density lipoproteins (LDL). Native LDL acquired platelet-activating ability only after oxidation. Flow-cytometric studies showed that CD62P and CD63 were rapidly expressed on platelets at a low concentration of oxidized LDL, indicating that they are more sensitive markers than platelet aggregation for detection of platelet activation by oxidized LDL. CD36 was found to be contributing to the binding and activation of platelets with oxidized LDL, but not to the binding of platelets with native LDL. Although the presence of oxidized LDL in plasma is known, its effect on platelet function remains to be studied.
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Takahashi et al. (1998) studied this question. Oxidized low-density lipoprotein (LDL) vs. Native LDL was evaluated on Platelet activation and binding (expression of CD62P, CD63, and CD36). Oxidized LDL induced rapid expression of CD62P and CD63 on platelets, and CD36 contributed to binding and activation, whereas native LDL did not.
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