Key result
Patients with subsegmental pulmonary embolism had a higher risk for PE recurrences during anticoagulation compared to those with central PE (adjusted HR 1.75; 95% CI 1.02-3.03).
Why the study?
The optimal therapy for patients with acute subsegmental pulmonary embolism remains controversial.
Does the anatomic location of pulmonary embolism (subsegmental vs segmental or central) affect the rate of symptomatic PE recurrences during anticoagulation?
Population
15 963 patients with a first episode of symptomatic PE
Comparison
Subsegmental vs segmental vs more central PE
Design
Registry-based cohort study
Follow-up
Median duration of therapy 179, 185, and 204 days, respectively
Authors
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Subsegmental PE was associated with higher recurrence risk on anticoagulation; leaves open whether location should guide therapy intensity or duration.
Cohort (n=15,963)
Yes
Does the anatomic location of pulmonary embolism (subsegmental vs segmental or central) affect the rate of symptomatic PE recurrences during anticoagulation?
Hazard Ratio: 1.75 (95% CI 1.02–3.03)
Patients with symptomatic subsegmental pulmonary embolism have a significantly higher risk of PE recurrence during anticoagulation compared to those with more central PE.
Fernández‐Capitán et al. (2020) conducted a cohort in First episode of symptomatic pulmonary embolism (n=15,963). Subsegmental pulmonary embolism vs. Segmental or more central pulmonary embolism was evaluated on Symptomatic PE recurrences during anticoagulation (adjusted HR 1.75, 95% CI 1.02-3.03). Patients with subsegmental pulmonary embolism had a higher risk for PE recurrences during anticoagulation compared to those with central PE (adjusted HR 1.75; 95% CI 1.02-3.03).
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