Key result
A 40-year-old female suffered a fatal simultaneous cardio-cerebral embolism caused by the destabilization of a single atherosclerotic plaque at the aortic sinotubular junction.
Why the study?
Strokes in young adults often have uncertain etiology, and simultaneous acute cardio-cerebral infarction is a rare manifestation where large artery atherosclerosis should be evaluated.
Case Report (n=1)
This case highlights the exceedingly rare phenomenon of simultaneous fatal cardio-cerebral thromboembolism in a young adult caused by the destabilization of a single atherosclerotic plaque at the aortic sinotubular junction.
Rare fatal simultaneous cardio-cerebral embolism from aortic plaque; hypothesis-generating for embolic sources in young adults.
Strokes in young adults present a challenging problem in terms of care and social impact. Most of cases in this cohort are classified as strokes of uncertain etiology. Application of multimodality diagnostic approach could help in the estimation of risk factors and underlying mechanisms. Simultaneous acute cardio-cerebral infarction is a rare manifestation, especially in young individuals. Large artery atherosclerosis should be excluded as a potential cause. Transesophageal echocardiography plays an important role in the diagnostic algorithm.The current article presents a clinical case of a fatal acute cardio-cerebral infarction in a 40-year old female without previous cardiovascular diseases and negative family history. Transesophageal echocardiography identified a large mobile thrombus at the sinotubular junction of ascending aorta. Transthoracic echocardiography revealed regional akinesia of the inferior wall, despite normal electrocardiogram. The autopsy findings confirmed co-occurrence of thromboembolic stroke in the right middle cerebral artery area and left ventricular inferior myocardial infarction due to thrombosis of the right coronary artery. This case documents an exceedingly rare phenomenon in this cohort of a cardio-cerebral thromboembolism due to single atherosclerotic plaque destabilization.
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Kavalerchyk et al. (2020) conducted a case report in Acute cardio-cerebral infarction (n=1). Mobile thrombus from aorta sinotubular junction atheroma was evaluated on Clinical outcome (mortality). A 40-year-old female suffered a fatal simultaneous cardio-cerebral embolism caused by the destabilization of a single atherosclerotic plaque at the aortic sinotubular junction.
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