Why the study?
Does intraperitoneal injection of pyran copolymer induce resistance against foot-and-mouth disease virus in mice?
Does intraperitoneal injection of pyran copolymer induce resistance against foot-and-mouth disease virus in mice?
Intraperitoneal injection of pyran copolymer induces a biphasic pattern of resistance against foot-and-mouth disease virus in mice, associated with serum interferon production.
Pyran-induced biphasic resistance in mice warrants no clinical change; leaves open whether interferon effects extend to other species or antiviral applications.
Mouse resistance to foot-and-mouth disease virus (FMDV) was induced by intraperitoneal injections of pyran copolymer. A biphasic pattern of protection occurred with greatest resistance 4 and 48 hr after injection of this polyanion. Viremia was not detectable in pretreated mice challenge-exposed with FMDV. Incubation of virus with pyran did not alter viral infectivity in mice or tissue culture. Serum interferon was demonstrated 1 and 2 days after pyran administration.
No takes yet. Share an insight, caveat, or question.
Jonathan Y. Richmond (1971) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: