Key result
Injection of microgram quantities of synthetic double-stranded RNA (poly I:C) induced host resistance to foot-and-mouth disease virus in mice, with protection lasting >48 hours.
May indicate antiviral potential of dsRNA mimics; leaves open translation from murine models to clinical application.
Synthetic 2-stranded RNA-a helical complex formed by duplexing homopolymers of polyriboinosinic and polyribocytidylic acids (poly I:C)-induced host resistance to foot-and-mouth disease virus when microgram quantities were injected into mice. There was a graded response as shown by titrations of polynucleotide complex or virus. Protection was effective for >48 hours after a single injection of polynucleotide complex. Survival and serum interferon titers were directly related.
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Richmond et al. (1969) studied Foot-and-mouth disease virus infection. Synthetic double-stranded RNA (poly I:C) was evaluated on Host resistance to foot-and-mouth disease virus. Injection of microgram quantities of synthetic double-stranded RNA (poly I:C) induced host resistance to foot-and-mouth disease virus in mice, with protection lasting >48 hours.
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