Key result
Congenital renal obstruction in rats decreased gene expression of renin (p<0.05 on day 1) and TGF-beta1 (p<0.05 during first 10 days) compared to controls during postpartum nephrogenesis.
Population
Rats from an inbred strain with congenital renal obstruction (72 renal units investigated)
Comparison
Congenital obstructive uropathy vs Contralateral kidneys and kidneys from healthy…
Design
Preclinical
Follow-up
up to 32 days post partum
Authors
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Rat model data on altered renin/TGF-beta1 expression do not inform clinical management; leaves open relevance to human congenital obstruction.
Congenital obstructed kidneys in rats show impaired nephrogenesis with altered renin and TGF-beta1 gene expression even before morphological signs of hydronephrosis.
Seseke et al. (2001) studied Congenital obstructive uropathy (n=72). Congenital renal obstruction vs. Contralateral kidneys and kidneys from healthy control animals was evaluated on Renal messenger RNA expression of renin and transforming growth factor-beta1 (TGF-beta1). Congenital renal obstruction in rats decreased gene expression of renin (p<0.05 on day 1) and TGF-beta1 (p<0.05 during first 10 days) compared to controls during postpartum nephrogenesis.
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