Key result
Unilateral ureteral obstruction in neonatal rats increased renal renin, angiotensin II, and AT1 receptor binding at 28 days, likely contributing to vasoconstriction and interstitial fibrosis.
Prolonged unilateral ureteral obstruction in neonatal rats leads to increased renal AT1 mRNA and receptor binding, likely contributing to vasoconstriction and interstitial fibrosis.
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Hypothesis-generating for RAS activation in neonatal obstruction; requires human validation before any clinical consideration.
Chronic unilateral ureteral obstruction (UUO) in early development activates the intrarenal renin-angiotensin system and leads to profound renal vasoconstriction, renal growth arrest, and interstitial fibrosis. To investigate the response of the AT1 and AT2 subtypes of the angiotensin II (ANG II) receptors to UUO, Sprague-Dawley rats underwent UUO or control sham operation in the first 48 h of life and were studied 1-28 days later. Renal mRNA for renin, AT1 and AT2 receptor, and receptor binding and distribution were determined. In contrast to controls, renin mRNA increased from 14 to 28 days in the obstructed kidney. After ipsilateral UUO, AT1 mRNA was suppressed at 1 day, but had increased compared with controls at 28 days. AT2 receptor mRNA fell rapidly in all kidneys from 1 to 3 days of age, after which it remained undetectable. Compared with the intact opposite kidney, AT2 mRNA was suppressed in the obstructed kidney 1 day after UUO. Compared with controls, AT1 and AT2 receptor binding was decreased by ipsilateral UUO at 1 day, whereas AT1 binding was increased at 28 days. Renal ANG II content was increased in the obstructed compared with the intact opposite kidney 28 days after UUO. In view of the increase in renal renin and angiotensin II production resulting from UUO, increased renal AT1 mRNA and receptor binding are likely to contribute to the vasoconstriction and interstitial fibrosis of the neonatal kidney after prolonged UUO.
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Yoo et al. (1997) studied Neonatal unilateral ureteral obstruction. Unilateral ureteral obstruction (UUO) vs. Control sham operation was evaluated on Renal mRNA for renin, AT1 and AT2 receptor, and receptor binding and distribution. Unilateral ureteral obstruction in neonatal rats increased renal renin, angiotensin II, and AT1 receptor binding at 28 days, likely contributing to vasoconstriction and interstitial fibrosis.
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