Key result
In rats with unilateral ureteral obstruction, angiotensin blockade attenuated renal eNOS protein expression at 1 day but not at 7 days, and ameliorated nephropathy.
Why the study?
Does angiotensin blockade (ACEI or ARB) alter renal eNOS and iNOS protein expression in a unilateral ureteral obstructive rat model?
Population
Male Wistar rats with unilateral ureteral obstruction (UUO) or sham operation
Comparison
Angiotensin converting enzyme inhibitor or… vs Water treatment in UUO rats, and sham-operated…
Design
Preclinical
Follow-up
1 or 7 days
Authors
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Angiotensin blockade effects in obstructive nephropathy should not change practice; hypothesis-generating for time-dependent eNOS modulation in renal injury.
Does angiotensin blockade (ACEI or ARB) alter renal eNOS and iNOS protein expression in a unilateral ureteral obstructive rat model?
In a rat model of unilateral ureteral obstruction, angiotensin blockade attenuates early but not late increases in renal eNOS expression and ameliorates structural nephropathy.
Tanyong et al. (2011) studied Unilateral ureteral obstruction. Angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor type 1 blocker (ARB) vs. Water (UUO control) and sham operation was evaluated on Renal eNOS and iNOS protein expression. In rats with unilateral ureteral obstruction, angiotensin blockade attenuated renal eNOS protein expression at 1 day but not at 7 days, and ameliorated nephropathy.
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