What does this research mean for the field?

Unilateral ureteral obstruction stimulates renin gene expression and intrarenal angiotensin II generation while suppressing tissue kallikrein expression, driving obstruction-induced hypertension and renal vasoconstriction. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 1, 1993AJP Renal Physiology

Upregulation of renin-angiotensin system and downregulation of kallikrein in obstructive nephropathy

Q: What are the key findings of this study?

Unilateral ureteral obstruction in rats increased renin mRNA and angiotensin II levels (P<0.05) while reducing tissue kallikrein mRNA to 25% of sham-operated kidneys (P<0.001).

Q: What is the clinical evidence from this study?

Study design: Other. Population: Obstructive nephropathy. Intervention: Unilateral ureteral obstruction vs. Sham-operated groups. Primary outcome: Renin mRNA levels, angiotensin II content, and tissue kallikrein mRNA levels (p=<0.001).

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Key result

Unilateral ureteral obstruction in rats increases renin and angiotensin II while reducing tissue kallikrein mRNA ~75%.

P<0.001

Authors

SESamir S. El‐DahrTulane University JGJulie GeeTulane University SDSusana DippOchsner Medical Center

Discussion

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Implication

May drive hypertension via intrarenal RAS-KKS imbalance in obstruction; leaves open whether kallikrein augmentation alters outcomes in humans.

PICO

Population

Rats subjected to prolonged (1 and 5 weeks) unilateral ureteral obstruction compared to sham-operated controls.

Intervention / Comparator

Unilateral ureteral obstruction vs Sham-operated groups

Primary Outcome

Renin mRNA levels, angiotensin II content, and tissue kallikrein mRNA levels, p=<0.001

Main Result

p-value: p=<0.001

Cite This Study

El‐Dahr et al. (1993) studied Obstructive nephropathy. Unilateral ureteral obstruction vs. Sham-operated groups was evaluated on Renin mRNA levels, angiotensin II content, and tissue kallikrein mRNA levels (p=<0.001). Unilateral ureteral obstruction in rats increased renin mRNA and angiotensin II levels (P<0.05) while reducing tissue kallikrein mRNA to 25% of sham-operated kidneys (P<0.001).

synapsesocial.com/papers/6aa4b902619ecad50f3d5ef5 https://doi.org/10.1152/ajprenal.1993.264.5.f874

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Implication

May drive hypertension via intrarenal RAS-KKS imbalance in obstruction; leaves open whether kallikrein augmentation alters outcomes in humans.

Upregulation of renin-angiotensin system and downregulation of kallikrein in obstructive nephropathy

Discussion

Member takes

Implication

PICO

Main Result

Cite This Study

Upregulation of renin-angiotensin system and downregulation of kallikrein in obstructive nephropathy

Discussion

Member takes

Implication

PICO

Main Result

Cite This Study

Also Consider

Also Consider