Key result
Graded Angiotensin 1-7 infusion significantly increased renal blood flow and decreased renal vascular resistance in sham, UUO, and RUUO rats, effects that were blocked by the Mas receptor antagonist A779 (P<0.005).
Why the study?
Does the Mas receptor antagonist A779 alter renal hemodynamic responses to Angiotensin 1-7 in rats with unilateral ureteral obstruction?
Does the Mas receptor antagonist A779 alter renal hemodynamic responses to Angiotensin 1-7 in rats with unilateral ureteral obstruction?
p-value: p=<0.005
Angiotensin 1-7 alters kidney hemodynamic responses in ureteral obstruction models via the Mas receptor, suggesting potential renoprotective effects.
Supports Mas-dependent renal vasodilation in rodent models; leaves open translation to human kidney disease.
Background: Unilateral ureteral obstruction (UUO) alters the expression of renin-angiotensin system (RAS) components and angiotensin 1-7 (Ang 1-7) as a main arm of RAS is affected by UUO. The role of Mas receptor antagonist (A779) was examined in renal hemodynamic responses to Ang 1-7 in 3-day UUO and UUO removal (RUUO) in rats. Materials and Methods: Forty-five male Wistar rats were randomly divided into three groups of sham operated, UUO, and RUUO, while each group was divided into two subgroups treated with vehicle or A779. Renal blood flow (RBF) and renal vascular resistance (RVR) responses to graded Ang 1-7 infusion were measured at controlled renal perfusion pressure. Results: Mean arterial pressure response to Ang 1-7 was increased in vehicle-treated subgroup significantly ( P < 0.05) when compared with A779-treated subgroup. However, such observation was not seen in UUO and RUUO rats. The graded Ang 1-7 infusion increased RBF and decreased RVR significantly in vehicle-treated rats ( P < 0.005). Furthermore, a significant difference was found between vehicle and A779-treated subgroups in sham, UUO, and RUUO groups ( P < 0.005). Conclusion: Ang 1-7 could alter the kidney hemodynamics responses in ureteral obstruction models.
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Hassanshahi et al. (2018) studied Unilateral ureteral obstruction (UUO) (n=45). Angiotensin 1-7 with or without Mas receptor antagonist (A779) vs. Vehicle (saline) was evaluated on Renal blood flow (RBF) and renal vascular resistance (RVR) responses to graded Ang 1-7 infusion (p=<0.005). Graded Angiotensin 1-7 infusion significantly increased renal blood flow and decreased renal vascular resistance in sham, UUO, and RUUO rats, effects that were blocked by the Mas receptor antagonist A779 (P<0.005).
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