Lipid-Lowering Property of Flavonoid-Rich Portion of Combretum Micranthumon High Fat Diet Induced Hyperlipidemic Rats

The lipid-lowering potential of flavonoid-rich portion of Combretum micranthum (CM) on a high-fat diet (HFD) induced albino rats was evaluated. Hyperlipidaemic rats were divided into six groups. Group I (Normal control), group II (HFD-fed only), while group III, IV and V received aqueous methanol (80%) leaf extract of CM at varied doses of 100, 200 and 400 mg/kg, respectively, while group VI were given the standard drug-Atorvastatin (4 mg/kg) for two weeks. Total Cholesterol (TC), Triacylglycerol (TAG), High Density Lipoproteins (HDL-C), Creatine Kinase (CK), and Lactate Dehydrogenase (LDH) were assayed spectrophotometrically and Atherogenic Index (AI) calculated using standard formula. GC-MS revealed 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, 5-oxycatechol and 1,2,3-benzene-triol to be the principal compounds. Significant reduction in TC, TAG, LDL-C, AI, CK, LDH and increased in HDL-C were observed compared to hyperlipidemic control (p<0.05) hence CM could be used in the management of risk of CVDs.