Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 1992Journal of VirologyOpen Access

The human immunodeficiency virus type 1 packaging signal and major splice donor region have a conserved stable secondary structure

View Full Paper
Ask AI
Bookmark
Share

Key result

Biochemical analysis and computer modelling revealed a highly structured conserved stem-loop in the HIV-1 packaging signal region that depends on base pairing between sequences 5' and 3' of the major splice donor.

Population

Human immunodeficiency virus type 1 (HIV-1) strain IIIB RNA sequences

Design

Preclinical

Authors

GHG P HarrisonGranta Design (United Kingdom)ALAndrew LeverAddenbrooke's Hospital

Discussion

Loading...

Member takes

Implication

May guide HIV packaging inhibitor design; leaves open therapeutic viability pending cellular and in vivo validation.

Structured PICO

P
Population
Human immunodeficiency virus type 1 (HIV-1) strain IIIB RNA sequences
E
Exposure
Biochemical analysis and computer modelling
O
Outcome
Secondary structure of the packaging signal regionsurrogate

The study identifies a conserved stable secondary structure in the HIV-1 packaging signal region that is critical for genomic RNA packaging.

Cite This Study

Harrison et al. (1992) studied Human immunodeficiency virus type 1 (HIV-1). Biochemical analysis and computer modelling was evaluated on Secondary structure of the packaging signal region. Biochemical analysis and computer modelling revealed a highly structured conserved stem-loop in the HIV-1 packaging signal region that depends on base pairing between sequences 5' and 3' of the major splice donor.

synapsesocial.com/papers/6a9445fecd4df3c00e00a2a6https://doi.org/10.1128/jvi.66.7.4144-4153.1992
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Secondary structure of a 345-base RNA fragment covering the S8/S15 protein binding domain of Escherichia coli 16 S ribosomal RNA1985 · 21 citations
  2. 2POSTTRANSCRIPTIONAL REGULATORY MECHANISMS IN ESCHERICHIA COLI1988 · 655 citations
  3. 3Secondary structure of the circular form of the Tetrahymena rRNA intervening sequence: a technique for RNA structure analysis using chemical probes and reverse transcriptase.1985 · 321 citations
  4. 4Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus1990 · 550 citations