Why the study?
Does chronic glyceryl trinitrate infusion cause pharmacological tolerance in a rat model of congestive heart failure?
Does chronic glyceryl trinitrate infusion cause pharmacological tolerance in a rat model of congestive heart failure?
This study demonstrates a rat model of congestive heart failure that successfully replicates the rapid development of in vivo nitrate tolerance seen in humans.
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Rat CHF model replicates rapid nitrate tolerance; extends human observations to preclinical research but leaves clinical translation open.
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Bauer et al. (1990) studied this question.
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