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Both sulfamethoxazole and trimethoprim exhibit physiologic-disposition characteristics which follow first order kinetics, whether the drugs are administered separately or in combination, in single or in multiple dosing regimens. Based on single-dose data, successful predictions of plateau levels in blood for each subject were obtained for both drugs. This finding substantiates the constancy of absorption, distribution, metabolism, and excretion of the drugs with each administration of the combination.
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Kaplan et al. (1973) studied this question.
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