September 1, 1991Clinical Physiology

Adenosine infusion to patients with ischaemic heart disease may provoke left ventricular dysfunction detected by echocardiography

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Why the study?

Does adenosine intravenous infusion provoke left ventricular wall motion abnormalities in patients with angiographically verified ischaemic heart disease?

Structured PICO

Does adenosine intravenous infusion provoke left ventricular wall motion abnormalities in patients with angiographically verified ischaemic heart disease?

Population

37 patients (6 female) aged 37-74 years with ischaemic heart disease (IHD) verified by coronary angiography.

Intervention

Adenosine intravenous infusion up to 200 micrograms/kg/min (mean 155 +/- 5) for 18 +/- 1 minutes.

Comparator

Basal state (pre-infusion).

Outcome

Occurrence and incidence of disturbances in left ventricular (LV) wall motion and Doppler indices of altered LV function.surrogate

Adenosine infusion frequently elicits myocardial ischaemia with LV wall motion abnormalities, suggesting its utility as an alternative to exercise for stress echocardiography.

Discussion

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Implication

Adenosine may enhance IHD detection on stress echocardiography; hypothesis-generating for randomized trials versus exercise.

Cite This Study

Edlund et al. (1991) studied this question.

synapsesocial.com/papers/6a944ebadc5e2315e7c5202e https://doi.org/10.1111/j.1475-097x.1991.tb00820.x

View Full Paper

Ask AI

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Adenosine infusion to patients with ischaemic heart disease may provoke left ventricular dysfunction detected by echocardiography

Structured PICO

Discussion

Implication

Cite This Study

Adenosine infusion to patients with ischaemic heart disease may provoke left ventricular dysfunction detected by echocardiography

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider