What is the clinical evidence from this study?

Study design: Other. Population: Foot-and-Mouth Disease Virus (FMDV) infection (n=20). Intervention: FMDV C-S8c1 infection vs. Uninfected controls. Primary outcome: Depletion of CD3+CD4-CD8+ and CD3+CD4-CD8+/- T cells (p=<0.05).

February 11, 2006Journal of VirologyOpen Access

Selective Lymphocyte Depletion during the Early Stage of the Immune Response to Foot-and-Mouth Disease Virus Infection in Swine

Q: What are the key findings of this study?

FMDV C-S8c1 infection in swine causes a profound, selective depletion of T and B lymphocytes during the early stage of infection, leading to transient immunosuppression.

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Key result

FMDV C-S8c1 infection in swine causes a profound, selective depletion of T and B lymphocytes during the early stage of infection, leading to transient immunosuppression.

Authors

FSFayna Díaz-San SegundoPlum Island Animal Disease Center FSFrancisco J. SalgueroDefence Science and Technology Laboratory AÁAna de ÁvilaUniversidade Estadual de Campinas (UNICAMP)

Discussion

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Implication

May heighten secondary infection risk in acutely infected swine; leaves open mechanisms of FMDV persistence across hosts.

PICO

Population

20 healthy 9-week-old female pigs, 16 inoculated with FMDV and 4 uninfected controls, followed for up to 17 days to observe early immune responses.

Intervention / Comparator

FMDV C-S8c1 infection vs Uninfected controls (10^5 PFU)

Primary Outcome

Depletion of CD3+CD4-CD8+ and CD3+CD4-CD8+/- T cells, p=<0.05

Main Result

p-value: p=<0.05

Limitations

The precise contribution of CD8+ lymphocytes during the onset of the immune response against FMDV is still unclear
The interaction of FMDV with other lymphoid cells such as dendritic cells requires further study

Cite This Study

Segundo et al. (2006) studied Foot-and-Mouth Disease Virus (FMDV) infection (n=20). FMDV C-S8c1 infection vs. Uninfected controls was evaluated on Depletion of CD3+CD4-CD8+ and CD3+CD4-CD8+/- T cells (p=<0.05). FMDV C-S8c1 infection in swine causes a profound, selective depletion of T and B lymphocytes during the early stage of infection, leading to transient immunosuppression.

synapsesocial.com/papers/6a945151bcfb83329ac57787 https://doi.org/10.1128/jvi.80.5.2369-2379.2006

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Selective Lymphocyte Depletion during the Early Stage of the Immune Response to Foot-and-Mouth Disease Virus Infection in Swine

Discussion

Member takes

Implication

PICO

Main Result

Limitations

Cite This Study

Selective Lymphocyte Depletion during the Early Stage of the Immune Response to Foot-and-Mouth Disease Virus Infection in Swine

Discussion

Member takes

Implication

PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider