Key result
High genetic risk for CAD conferred a 2.4-fold higher risk of incident CAD in men compared to an 80% greater risk in women (interaction P=0.002).
Why the study?
Sex differences have not been fully examined in the applications of genetic risk scores for coronary artery disease.
Does the association between genetic risk scores and coronary artery disease differ between men and women?
Population
317 509 unrelated individuals of European ancestry from the UK Biobank
Comparison
Genetic risk score associations and interactions in men vs women
Design
Cohort study
Authors
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Sex differences in genetic CAD risk may inform stratified models; hypothesis-generating and requires prospective validation before practice change.
Cohort (n=317,509)
Does the association between genetic risk scores and coronary artery disease differ between men and women?
Effect estimate: 2.4x higher risk (men) vs 80% greater risk (women)
p-value: p=0.002
Genetic risk scores for coronary artery disease demonstrate a stronger association with CAD risk in men than in women, indicating that genetic predisposition assessments should account for sex differences.
Huang et al. (2020) conducted a cohort in Coronary artery disease (n=317,509). High genetic risk for CAD (CAD-GRS) vs. Low genetic risk was evaluated on Incident CAD (2.4x higher risk (men) vs 80% greater risk (women), p=0.002). High genetic risk for CAD conferred a 2.4-fold higher risk of incident CAD in men compared to an 80% greater risk in women (interaction P=0.002).
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