Key result
Health-related quality of life in pre-schoolers with single-ventricle CHD was comparable to children with biventricular CHD, with perioperative variables explaining 24% of score variability.
Why the study?
Little is known about health-related quality of life in young children undergoing staged palliation for single-ventricle CHD.
What is the health-related quality of life and its determinants in pre-school age children with single-ventricle CHD compared to those with biventricular CHD?
Cohort (n=46)
Yes
What is the health-related quality of life and its determinants in pre-school age children with single-ventricle CHD compared to those with biventricular CHD?
Pre-schoolers with single-ventricle CHD have comparable health-related quality of life to those with biventricular CHD, primarily influenced by preterm birth and perioperative factors.
Answers are grounded in this paper and cite their sources.
Comparable HRQoL in single-ventricle pre-schoolers supports similar counseling; leaves open perioperative optimization as a modifiable target.
BACKGROUND: Little is known about health-related quality of life in young children undergoing staged palliation for single-ventricle CHD. The aim of this study was to assess the impact of CHD on daily life in pre-schoolers with single-ventricle CHD and to identify determinants of health-related quality of life. METHOD: Prospective two-centre cohort study assessing health-related quality of life using the Preschool Paediatric Cardiac Quality of Life Inventory in 46 children at a mean age of 38 months and 3 weeks. Children with genetic anomalies were excluded. Scores were compared with reference data of children with biventricular CHD. Multiple linear regression analysis was used to identify determinants of health-related quality of life. RESULTS: Health-related quality of life in pre-schoolers with single-ventricle CHD was comparable to children with biventricular CHD. Preterm birth and perioperative variables were significant predictors of low health-related quality of life. Notably, pre-Fontan brain MRI findings and neurodevelopmental status were not associated with health-related quality of life. Overall, perioperative variables explained 24% of the variability of the total health-related quality of life score.InterpretationDespite substantial health-related burden, pre-schoolers with single-ventricle CHD showed good health-related quality of life. Less-modifiable treatment-related risk factors and preterm birth had the highest impact on health-related quality of life. Long-term follow-up assessment of self-reported health-related quality of life is needed to identify patients with poorer health-related quality of life and to initiate supportive care.
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Heye et al. (2019) conducted a cohort in Single-ventricle congenital heart disease (CHD) (n=46). Single-ventricle CHD vs. Children with biventricular CHD (reference data) was evaluated on Health-related quality of life assessed using the Preschool Paediatric Cardiac Quality of Life Inventory. Health-related quality of life in pre-schoolers with single-ventricle CHD was comparable to children with biventricular CHD, with perioperative variables explaining 24% of score variability.
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