Postoperative congenital heart disease patients had substantially worse physical function compared with healthy controls (SMD -0.56; 95% CI -0.82 to -0.30).
Meta-Analysis (n=3,808)
Does congenital heart disease surgery result in different health-related quality of life compared to healthy controls in children and young adults?
Children and young adults who have undergone congenital heart disease surgery have substantially worse health-related quality of life compared to healthy controls, particularly in physical function.
Standardized Mean Difference: -0.56 (95% CI -0.82–-0.3)
BACKGROUND: As survival improves in the congenital heart disease (CHD) population, health-related quality of life (HRQOL) outcomes become increasingly important. While surgery improves survival, poor HRQOL occurs postoperatively and cardiac-related HRQOL outcomes are rarely reported. OBJECTIVE: To conduct a systematic review and meta-analyses of general and cardiac-related HRQOL in CHD surgical children and young adults. METHOD: Medline, CINAHL and EMBASE were searched. Quantitative designs with a minimum of 80% CHD surgical patients and mean age ≤18 years compared with healthy controls were included in the review. Data were analysed in RevMan V.5.3 using a random effects model. OUTCOME MEASURES: General and cardiac-related HRQOL. RESULTS: Studies (n=20) were conducted in high-income countries and included 3808 patients plus 2951 parental reports of patients. HRQOL was worse in postoperative patients with CHD versus healthy controls in all domains with the largest difference seen for physical function (standard mean difference (SMD) of -0.56, 95% CI -0.82 to -0.30). Cardiac-related HRQOL was worse in complex compared with simple CHD with the largest SMD (-0.60, 95% CI -0.80 to -0.40) for symptoms. Heterogeneity ranged from 0% to 90%. CONCLUSIONS: CHD surgical patients have substantially worse HRQOL compared with age-matched healthy controls. Strategies should focus on improving HRQOL in this subgroup. Results may not be applicable to low/middle-income countries given the dearth of relevant research.
Ladak et al. (Fri,) conducted a meta-analysis in Congenital heart disease (n=3,808). Congenital heart disease surgery vs. Healthy controls was evaluated on Physical function (HRQOL domain) (SMD -0.56, 95% CI -0.82 to -0.30). Postoperative congenital heart disease patients had substantially worse physical function compared with healthy controls (SMD -0.56; 95% CI -0.82 to -0.30).